Patient-derived cell line, xenograft and organoid models in lung cancer therapy

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

establishment of autochthonous & standard cell line derived xenograft models of glioblastoma multiform in iran

background: gbm is the most common and malignant astrocity tumor and it is persistent to common treatment so, these patients have a very low survival. several researchers around the world, including iran, have been investigated gbm-cell line in vitro. however in vivo studies have not been fulfilled. methods : as standard cell line (u-87mg) derived from human gbm and total gbm tumor derived from...

متن کامل

Comparing Patient-Derived Xenograft and Computational Response Prediction for Targeted Therapy in Patients of Early-Stage Large Cell Lung Cancer.

PURPOSE Targeted therapy (TT) provides highly effective cancer treatment for appropriately selected individuals. A major challenge of TT is to select patients who would benefit most. EXPERIMENTAL DESIGN The study uses cancer material from 25 patients primarily diagnosed with non-small cell lung cancer (NSCLC). Patient-derived xenografts (PDXs) are treated with cetuximab and erlotinib. Treatme...

متن کامل

Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer and Their Potential Utility in Personalized Medicine

Traditional preclinical studies of cancer therapeutics have relied on the use of established human cell lines that have been adapted to grow in the laboratory and, therefore, may deviate from the cancer they were meant to represent. With the emphasis of cancer drug development shifting from non-specific cytotoxic agents to rationally designed molecularly targeted therapies or immunotherapy come...

متن کامل

Association of EGFR expression level and cetuximab activity in patient-derived xenograft models of human non-small cell lung cancer.

PURPOSE To explore in a panel of patient-derived xenograft models of human non-small cell lung cancer (NSCLC) whether high EGFR expression, was associated with cetuximab activity. EXPERIMENTAL DESIGN NSCLC patient-derived xenograft models (n=45) were implanted subcutaneously into panels of nude mice and randomization cohorts were treated with either cetuximab, cisplatin, cisplatin plus cetuxi...

متن کامل

Genomic Profiling of Patient-Derived Colon Cancer Xenograft Models

Recent evidence suggests that patient derived xenograft (PDX) models can maintain certain pathological and molecular features of the original disease. However, these characterizations are limited to immunohistochemistry or by tissue microarray analysis. We conducted a high-throughput sequencing of primary colon tumor and PDX has not been reported yet. Fresh primary colon cancer tissues that ori...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Translational Lung Cancer Research

سال: 2020

ISSN: 2218-6751,2226-4477

DOI: 10.21037/tlcr-20-154